Ulipristal acetate in emergency contraception: mechanism of action.
نویسندگان
چکیده
These conclusions are shared by most authoritative international drug administrations. The USA FDA just adds that alterations to the endometrium might possibly contribute to UPA efficacy (http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022474s000lbl.pdf), whereas the European Medicines Agency only mentions ovulatory delay (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Product_Information/human/001027/WC500023670.pdf). Most respected scientific societies (http://www.sigo.it/usr_files/home/guidelines.pdf) and many reviews rely completely on those conclusions [2] and report that ellaOne ® , administered immediately before ovulation, significantly delays follicular rupture.
منابع مشابه
Mechanism of Action of Ulipristal Acetate for Emergency Contraception: A Systematic Review
Ulipristal acetate (UPA) is now recommended as first choice hormonal emergency contraception (EC), due to its higher efficacy and similar safety compared to Levonorgestrel - EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fost...
متن کاملEmergency Contraception: An Updated Review
Emergency contraception is a common practice now. Many categories of drugs are marketed with modifications in dosage, in combination and even in the timing of administration. Recent re-analysis suggests that there is still no uniformity of opinion on the actual mechanism of action and this has often fueled the ethical controversy. This review analyzes the most common emergency contraception dru...
متن کاملEmergency contraception review: evidence-based recommendations for clinicians.
Several options for emergency contraception are available in the United States. This article describes each method, including efficacy, mode of action, safety, side effect profile, and availability. The most effective emergency contraceptive is the copper intrauterine device (IUD), followed by ulipristal acetate and levonorgestrel pills. Levonorgestrel is available for sale without restrictions...
متن کاملMechanisms of action of oral emergency contraception.
This review gives an overview of the mechanisms of action of oral emergency contraception pills (ECPs), focusing on the levonorgestrel (LNG) and ulipristal acetate (UPA) containing ECPs. In vivo and in vitro studies have addressed the effect of EC on various possible targets. Based on these studies as well as on clinical trials it is clear that the efficacy of ECPs to prevent an unintended preg...
متن کاملUlipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis.
BACKGROUND Emergency contraception can prevent unintended pregnancies, but current methods are only effective if used as soon as possible after sexual intercourse and before ovulation. We compared the efficacy and safety of ulipristal acetate with levonorgestrel for emergency contraception. METHODS Women with regular menstrual cycles who presented to a participating family planning clinic req...
متن کاملUlipristal acetate emergency contraception.
I read with interest the letter by Webb et al. about the pitfalls of adapting the Clinical Effectiveness Unit’s guidance on emergency contraception (EC). Their letter discusses, in relation to maximising the pharmacodynamic attributes of ulipristal acetate (UA), the significant inaccuracies inherent in the calculation of the timing of ovulation based on the menstrual history. However, we freque...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Trends in pharmacological sciences
دوره 34 4 شماره
صفحات -
تاریخ انتشار 2013